The Kinetics of Glomerular Deposition of Nephritogenic IgA
نویسندگان
چکیده
منابع مشابه
The Kinetics of Glomerular Deposition of Nephritogenic IgA
Whether IgA nephropathy is attributable to mesangial IgA is unclear as there is no correlation between intensity of deposits and extent of glomerular injury and no clear mechanism explaining how these mesangial deposits induce hematuria and subsequent proteinuria. This hinders the development of a specific therapy. Thus, precise events during deposition still remain clinical challenge to clarif...
متن کاملThe glomerular response to IgA deposition in IgA nephropathy.
Compelling evidence points to a role for IgA receptors in the pathogenesis of IgA nephropathy. The soluble form of the type I IgA receptor (FcalphaRI or CD89) forms complexes with IgA that can be found in patients' serum and that initiate the disease in CD89 transgenic mice. A nonclassic IgA receptor, identified as the transferrin receptor (TfR), is highly expressed in patients' mesangium and c...
متن کاملGlomerular IgA deposition in liver disease.
like lesion, occasionally with IgA and IgM deposition, Introduction and characteristic ultrastructural changes including endothelial cytoplasmic projections and granular matIgA nephropathy associated with liver disease (hepatic erial in a widened subendothelial space with clusters IgAN) is the commonest form of secondary IgAN. It of vesicles in the mesangium and glomerular capillary is particul...
متن کاملUncoupling of Glomerular IgA Deposition and Disease Progression in Alymphoplasia Mice with IgA Nephropathy
Previous clinical and experimental studies have indicated that cells responsible for IgA nephropathy (IgAN), at least in part, are localized in bone marrow (BM). Indeed, we have demonstrated that murine IgAN can be experimentally reconstituted by bone marrow transplantation (BMT) from IgAN prone mice in not only normal mice, but also in alymphoplasia mice (aly/aly) independent of IgA+ cells hom...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS ONE
سال: 2014
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0113005